Foldit is a citizen-science game developed at the University of Washington by David Baker, Zoran Popović, Seth Cooper, and Adrien Treuille. Players manipulate three-dimensional protein structures using an intuitive toolkit — wiggle, shake, rubber bands, rebuild — and are scored by the Rosetta energy function, which measures the thermodynamic plausibility of each conformation. The game is, in essence, a translation of one of the hardest unsolved problems in computational biology into a spatial puzzle that human hands and eyes can address. In 2011, Foldit players solved the crystal structure of the Mason-Pfizer monkey virus (M-PMV) retroviral protease in three weeks — a problem that automated methods had failed to crack for a decade. It was the first scientific problem solved by gamers, and the resulting paper in Nature Structural & Molecular Biology listed the players as co-authors. Since then, Foldit players have designed novel proteins published in Nature, improved enzyme activity eighteen-fold in a study published in Nature Biotechnology, developed folding algorithms that rival those of professional scientists in work published in PNAS, and contributed over 20,000 candidate designs for COVID-19 antiviral proteins. David Baker, whose laboratory created both the Rosetta software and the game that made it playable, shared the 2024 Nobel Prize in Chemistry for computational protein design. The Academy hosts Foldit in the Mind School because its central exercise is spatial reasoning at the molecular scale: the player's intuition, harnessed by the game's mechanics, produces genuine scientific discovery.